Brian  F. Gage, MD, MSc

Brian F. Gage, MD, MSc

Professor of Medicine


Brian F. Gage, MD, MSc is a physician–scientist whose research focuses on antithrombotic therapy and thrombosis. He is a Professor of Medicine at Washington University in St. Louis where he teaches Designing Outcomes & Clinical (DOC) Research. He sees patients at Barnes-Jewish Hospital, where he directs the Clinical-Scientist Teaching And Research (C-STAR) program for medical residents. He also directs the Washington University Fellowship in General Medicine & Geriatrics (GMS Fellowship).

Dr. Gage has a BS (biology) and MSc (health services research) from Stanford University and an MD from the University of California, San Diego. He completed his internship and chief residency at the Good Samaritan/Phoenix VA Medical Center, his internal medicine residency at Barnes-Jewish Hospital, and his fellowship (in general internal medicine) at the Palo Alto VA/Stanford University.  He is board-certified in internal medicine.

Dr. Gage studies antithrombotic therapy and thrombosis. He was the principal investigator of the recently completed Genetic InFormatics Trial (GIFT) of Warfarin Therapy to Prevent DVT Trial.  GIFT compared pharmacogenetic to clinical dosing of warfarin therapy in a multi-centered trial of ~1600 participants. To make the GIFT dosing algorithms publicly available, he operates a non-profit website, ( that guides warfarin initiation. He also has helped develop clinical prediction rules to predict stroke (CHADS2) and hemorrhage (HEMORR2HAGES) in patients with atrial fibrillation or with acute coronary syndrome and (CRUSADE Bleeding Rule).

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